| Therapy of focal and segmental glomerulosclerosis with methylprednisolone, cyclosporine A, and prednisone. | |
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MedLine Citation:
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PMID: 9686959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with steroid-resistant focal and segmental glomerulosclerosis (FSGS) have a poor prognosis but may benefit from high-dose methylprednisolone or cyclosporine A therapy. Ten patients were treated with a protocol of methylprednisolone infusions for 8 weeks followed by a combination of cyclosporine A and alternate-day prednisone for maintenance of remission for 2 weeks. Eight of ten patients remitted the nephrotic syndrome within 8 weeks of beginning treatment. One patient remitted edema but remained proteinuric, and one did not respond. After observation for 12-24 months, seven patients maintained remission with normal glomerular filtration rate. One non-responder had renal insufficiency and one patient had secondary non-response and end-stage renal disease. No patients developed hypertension. One patient had the diagnosis of Hodgkin disease made after 10 months of therapy. Follow-up renal biopsy in four patients showed no evidence of progressive interstitial disease. There were no other major side effects. Steroid-resistant FSGS may be successfully treated with the described protocol. Additional studies will be needed to determine if this approach prevents progression of renal disease. |
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Authors:
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F B Waldo; M R Benfield; E C Kohaut |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 12 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-10-02 Completed Date: 1998-10-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 397-400 Citation Subset: IM |
Affiliation:
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University of Alabama at Birmingham, Department of Pediatrics, Children's Hospital, 35233, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-Inflammatory Agents / administration & dosage* Child Child, Preschool Cyclosporine / administration & dosage* Drug Therapy, Combination Female Glomerulosclerosis, Focal Segmental / drug therapy* Humans Immunosuppressive Agents / administration & dosage* Infusions, Intravenous Male Methylprednisolone / administration & dosage* Prednisone / administration & dosage* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 53-03-2/Prednisone; 59865-13-3/Cyclosporine; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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