| Therapy of chronic idiopathic thrombocytopenic purpura in adults: experiences from Thailand. | |
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MedLine Citation:
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PMID: 7886612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Results of different types of treatment in 416 adults with chronic idiopathic thrombocytopenic purpura (ITP) were analyzed. Of 368 patients treated with corticosteroids, 278 (77%) achieved complete response (CR ie, normalization of platelet count). However, only 18% of patients had continued complete response (CCR). Results of splenectomy was analyzed in 126 patients, 49% of them achieved CCR and 76% of them had beneficial effects from the operation. Emergency splenectomy was a life saving procedure in 8 of 11 patients with life-threatening hemorrhage. Vinca alkaloids gave a 50% transient CR. Immunosuppressive agents (cyclophosphamide, azathioprine) resulted in only 11% CCR. |
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Authors:
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W Wanachiwanawin; S Visudhiphan; A Pinankijagum; S Vatanavicharn |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Southeast Asian journal of tropical medicine and public health Volume: 24 Suppl 1 ISSN: 0125-1562 ISO Abbreviation: Southeast Asian J. Trop. Med. Public Health Publication Date: 1993 |
Date Detail:
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Created Date: 1995-04-13 Completed Date: 1995-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0266303 Medline TA: Southeast Asian J Trop Med Public Health Country: THAILAND |
Other Details:
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Languages: eng Pagination: 71-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chronic Disease Female Humans Immunosuppressive Agents / therapeutic use Male Prednisolone / therapeutic use* Purpura, Thrombocytopenic, Idiopathic / drug therapy, surgery, therapy* Splenectomy* Thailand Treatment Outcome Vinca Alkaloids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Vinca Alkaloids; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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