Document Detail

Therapy of chronic idiopathic thrombocytopenic purpura in adults: experiences from Thailand.
MedLine Citation:
PMID:  7886612     Owner:  NLM     Status:  MEDLINE    
Results of different types of treatment in 416 adults with chronic idiopathic thrombocytopenic purpura (ITP) were analyzed. Of 368 patients treated with corticosteroids, 278 (77%) achieved complete response (CR ie, normalization of platelet count). However, only 18% of patients had continued complete response (CCR). Results of splenectomy was analyzed in 126 patients, 49% of them achieved CCR and 76% of them had beneficial effects from the operation. Emergency splenectomy was a life saving procedure in 8 of 11 patients with life-threatening hemorrhage. Vinca alkaloids gave a 50% transient CR. Immunosuppressive agents (cyclophosphamide, azathioprine) resulted in only 11% CCR.
W Wanachiwanawin; S Visudhiphan; A Pinankijagum; S Vatanavicharn
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  24 Suppl 1     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  1993  
Date Detail:
Created Date:  1995-04-13     Completed Date:  1995-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Chronic Disease
Immunosuppressive Agents / therapeutic use
Prednisolone / therapeutic use*
Purpura, Thrombocytopenic, Idiopathic / drug therapy,  surgery,  therapy*
Treatment Outcome
Vinca Alkaloids / therapeutic use
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Vinca Alkaloids; 50-24-8/Prednisolone

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