Document Detail


Therapy Insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndrome.
MedLine Citation:
PMID:  16990829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The introduction of combination antiretroviral therapy for HIV infection has prolonged the lives of patients with AIDS. It is increasingly being recognized, however, that following initiation of this therapy some patients can develop a paradoxical neurological deterioration, despite dramatic improvements in HIV viral load and CD4+ T-cell counts. This immune reconstitution inflammatory syndrome (IRIS) in the CNS is emerging as an important neurological complication, particularly as antiretroviral therapy is now becoming readily available worldwide. Currently, there are no guidelines for prevention, diagnosis or treatment of the CNS manifestations of IRIS. Even in patients with an acute presentation, the diagnosis can be challenging. Furthermore, it is possible that more-chronic forms of the syndrome exist but remain unrecognized. Here, we review the various clinical presentations of CNS IRIS, and discuss options for their management.
Authors:
David J Riedel; Carlos A Pardo; Justin McArthur; Avindra Nath
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature clinical practice. Neurology     Volume:  2     ISSN:  1745-834X     ISO Abbreviation:  Nat Clin Pract Neurol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-22     Completed Date:  2006-11-14     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101261799     Medline TA:  Nat Clin Pract Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / complications
Antiretroviral Therapy, Highly Active / adverse effects*
Brain Diseases / chemically induced*,  diagnosis*,  immunology
HIV Infections / complications,  drug therapy*
Humans
Inflammation
Grant Support
ID/Acronym/Agency:
K08 DA016160/DA/NIDA NIH HHS; K08 DA016160-03/DA/NIDA NIH HHS; K08DA016160/DA/NIDA NIH HHS; P01MH070306/MH/NIMH NIH HHS; P01MH70056/MH/NIMH NIH HHS; R01NS039253/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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