Document Detail


Therapies with emerging evidence of efficacy: avotermin for the improvement of scarring.
MedLine Citation:
PMID:  20811604     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Many patients are dissatisfied with scars on both visible and non-visible body sites and would value any opportunity to improve or minimise scarring following surgery. Approximately 44 million procedures in the US and 42 million procedures in the EU per annum could benefit from scar reduction therapy. A wide range of non-invasive and invasive techniques have been used in an attempt to improve scarring although robust, prospective clinical trials to support the efficacy of these therapies are lacking. Differences in wound healing and scar outcome between early fetal and adult wounds led to interest in the role of the TGFbeta family of cytokines in scar formation and the identification of TGFbeta3 (avotermin) as a potential therapeutic agent for the improvement of scar appearance. Extensive pre-clinical and human Phase I and II clinical trial programmes have confirmed the scar improving efficacy of avotermin which produces macroscopic and histological improvements in scar architecture, with improved restitution of the epidermis and an organisation of dermal extracellular matrix that more closely resembles normal skin. Avotermin is safe and well tolerated and is currently in Phase III of clinical development, with the first study, in patients undergoing scar revision surgery, fully recruited.
Authors:
Jim Bush; Karen So; Tracey Mason; Nick L Occleston; Sharon O'Kane; Mark W J Ferguson
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Publication Detail:
Type:  Journal Article     Date:  2010-08-03
Journal Detail:
Title:  Dermatology research and practice     Volume:  2010     ISSN:  1687-6113     ISO Abbreviation:  Dermatol Res Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312803     Medline TA:  Dermatol Res Pract     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Affiliation:
Renovo, Core Technology Facility, 48 Grafton Street, Manchester M13 9XX, UK.
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