Document Detail


Therapies for scleroderma-related pulmonary arterial hypertension.
MedLine Citation:
PMID:  19885388     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pulmonary arterial hypertension (PAH), a common complication of systemic sclerosis, carries a very severe prognosis and is one of the leading causes of death in patients who suffer from it. Indeed, response to modern medical therapy has been disappointing in scleroderma-related PAH compared with other forms of PAH from the WHO group 1 classification of diseases, despite similar histological changes involving the pulmonary vasculature. This review discusses specific features of scleroderma-related PAH, currently available and US FDA-approved therapy for this syndrome, as well as potential future therapeutic developments based on newly acquired knowledge of this disorder.
Authors:
Paul M Hassoun
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  3     ISSN:  1747-6348     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  187-196     Citation Subset:  -    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA, Tel.: +1 410 614 5158, , phassoun@jhmi.edu.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P50 HL084946-01//NHLBI NIH HHS

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