| Therapies for coronaviruses. Part 2: Inhibitors of intracellular life cycle. | |
| | |
MedLine Citation:
|
PMID: 19441924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Severe acute respiratory syndrome (SARS) coronavirus emerged from an animal reservoir in 2002 and has the potential to reemerge, as shown by the occurrence of non-laboratory-associated new cases in the winter of 2003. In the absence of a vaccine, broad spectrum anticoronaviral medications are needed. OBJECTIVE: Anticoronavirals targeting viral entry were reviewed in part I. Here we review anticoronaviral therapies directed against the intracellular life cycle, with an emphasis on allowed patents and pending patents. METHOD: The published literature, in particular, patent publications is searched for relevant documents. The information is organized and critiqued. RESULTS/CONCLUSION: Many promising anticoronaviral strategies are identified. Monoclonal antibodies, protease inhibitors, interferon-based drugs and nucleic-acid based antivirals are most advanced, each having its own advantages and disadvantages. A multi-pronged approach, keeping all venues open, is advocated. |
| | |
Authors:
|
Tommy R Tong |
Related Documents
:
|
20642314 - Summary report of journal operations, 2009. 22448114 - Review of australasian spider flies (diptera, acroceridae) with a revision of panops la... 8727104 - Setting reactions in dental amalgam. part 1. phases and microstructures between one hou... 1501184 - Effects of environmental factors on maxillofacial elastomers: part i--literature review. 10707364 - Histological features of resolving acute, non-complicated phlegmonous appendicitis. 16877994 - The congenital intrahepatic arterioportal fistula syndrome: elucidation and proposed cl... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Expert opinion on therapeutic patents Volume: 19 ISSN: 1744-7674 ISO Abbreviation: Expert Opin Ther Pat Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-05-15 Completed Date: 2009-07-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9516419 Medline TA: Expert Opin Ther Pat Country: England |
Other Details:
|
Languages: eng Pagination: 415-31 Citation Subset: IM |
Affiliation:
|
Jack D Weiler Hospital, Montefiore Medical Center, Department of Pathology, 1825 Eastchester Road, Bronx, NY 10461, USA. ttong@montefiore.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antiviral Agents / pharmacology* Coronavirus / drug effects* Coronavirus Infections / drug therapy*, virology Humans Patents as Topic SARS Virus / drug effects Severe Acute Respiratory Syndrome / drug therapy, virology |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sirtuin activators.
Next Document: Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection...