| Therapeutics interventions with anti-inflammatory creams in post radiation acute skin reactions: a systematic review of most important clinical trials. | |
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MedLine Citation:
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PMID: 20100164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The majority of cancer patients will receive radiation therapy treatment at some stage during their malignancy. An acute skin reaction represents a common post radiation side effect with different grade of severity. In order to investigate the optimal methods to prevent and manage acute skin reactions related to radiation therapy we have conducted a systematic review on this topic. It seems that skin washing, including gentle washing with water alone with or without mild soap, should be permitted in patients receiving radiation therapy, to prevent acute skin reaction. In addition, a low dose (i.e., 1%) corticosteroid cream may be beneficial in the reduction of itching and irritation. We have concluded that there is insufficient evidence to support or refute specific topical or oral agents for the prevention or management of acute skin reaction. There is a need for further research to review treatments that have produced promising results in the reviewed research studies and to evaluate other commonly recommended topical treatments. The purpose of this patent and literature review is to advocate the current management of acute skin reaction. |
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Authors:
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Georgios V Koukourakis; Nikolaos Kelekis; John Kouvaris; Ivelina K Beli; Vassilios E Kouloulias |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Recent patents on inflammation & allergy drug discovery Volume: 4 ISSN: 1872-213X ISO Abbreviation: Recent Pat Inflamm Allergy Drug Discov Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-06 Revised Date: 2011-06-17 |
Medline Journal Info:
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Nlm Unique ID: 101309297 Medline TA: Recent Pat Inflamm Allergy Drug Discov Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 149-58 Citation Subset: IM |
Affiliation:
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Second Radiation Therapy Department, Saint Savvas Anticancer Institute of Athens, Athens, Greece. vkouloul@cc.ece.ntua.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Cutaneous Animals Anti-Inflammatory Agents / administration & dosage, therapeutic use* Clinical Trials as Topic Dermatologic Agents / therapeutic use Glucocorticoids / administration & dosage, therapeutic use* Humans Neoplasms / radiotherapy Patents as Topic Radiodermatitis / drug therapy*, prevention & control Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Dermatologic Agents; 0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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