Document Detail

Therapeutic vaccination for future management of HIV/AIDS.
MedLine Citation:
PMID:  12531329     Owner:  NLM     Status:  MEDLINE    
The investigation of novel and innovative treatment approaches for long-term management of HIV-infection has intensified due to the growing number of infected individuals worldwide and the constraints of resistance, toxicity and inconvenience associated with lifelong therapy. Current treatment relies entirely on antiretroviral drugs targeting various stages of the life cycle of HIV, rather than on leveraging the immune system. However, the boosting of HIV-specific immune responses in chronic infection offers a vast potential for synergy with antiretroviral drugs, thereby contributing to durable control of viral replication. A novel immunotherapeutic agent that delivers plasmid DNA to dendritic cells after topical skin application is the first therapeutic vaccine that has demonstrated immunological and clinical benefit in chronically infected rhesus macaques in combination with antiretroviral therapy.
Julianna Lisziewicz; Nyasha Bakare; Franco Lori
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Vaccine     Volume:  21     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-17     Completed Date:  2003-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  620-3     Citation Subset:  IM    
Research Institute for Genetic and Human Therapy (RIGHT), 2233 Wisconsin Avenue NW Suite 503, Washington, DC 20007, USA.
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MeSH Terms
AIDS Vaccines / therapeutic use*
Acquired Immunodeficiency Syndrome / immunology,  prevention & control
Anti-HIV Agents / therapeutic use
Antiretroviral Therapy, Highly Active
Combined Modality Therapy
HIV Infections / drug therapy*,  immunology,  prevention & control*
Immunotherapy / methods
Reg. No./Substance:
0/AIDS Vaccines; 0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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