| Therapeutic use of surfactant components in allergic asthma. | |
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MedLine Citation:
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PMID: 18854984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary surfactant is a complex mixture of lipids and proteins that reduces the surface tension at the air-liquid interface. In addition to its biophysical function, some surfactant components play an important role for the innate and adaptive immunity of the lung. A negative modulation of the surfactant function was observed in allergic asthma leading to the assumption that the therapeutic application of surfactant components might be beneficial in this disease. So far, there are a number of preclinical and already some clinical studies demonstrating various effects of different surfactant components that were administered with preventive or therapeutic aim in allergic asthma. This review summarizes the current knowledge on the possibilities to treat allergic asthma with surfactant components. |
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Authors:
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Veit J Erpenbeck; Norbert Krug; Jens M Hohlfeld |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-10-15 |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 379 ISSN: 1432-1912 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-03 Completed Date: 2009-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 217-24 Citation Subset: IM |
Affiliation:
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Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany. veit.erpenbeck@merck.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Asthmatic Agents / chemistry, metabolism, therapeutic use* Antigen Presentation / drug effects Asthma / drug therapy*, immunology Humans Pulmonary Surfactant-Associated Proteins / immunology, metabolism Pulmonary Surfactants / chemistry, metabolism, therapeutic use* Respiratory System / drug effects, immunology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents; 0/Pulmonary Surfactant-Associated Proteins; 0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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