Document Detail


Therapeutic use of omega-3 fatty acids in severe head trauma.
MedLine Citation:
PMID:  22867826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Traumatic brain injury (TBI) has long been recognized as the leading cause of traumatic death and disability. Tremendous advances in surgical and intensive care unit management of the primary injury, including maintaining adequate oxygenation, controlling intracranial pressure, and ensuring proper cerebral perfusion pressure, have resulted in reduced mortality. However, the secondary injury phase of TBI is a prolonged pathogenic process characterized by neuroinflammation, excitatory amino acids, free radicals, and ion imbalance. There are no approved therapies to directly address these underlying processes. Here, we present a case that was intentionally treated with substantial amounts of omega-3 fatty acids (n-3FA) to provide the nutritional foundation for the brain to begin the healing process following severe TBI. Recent animal research supports the use of n-3FA, and clinical experience suggests that benefits may be possible from substantially and aggressively adding n-3FA to optimize the nutritional foundation of severe TBI patients and must be in place if the brain is to be given the opportunity to repair itself to the best possible extent. Administration early in the course of treatment, in the emergency department or sooner, has the potential to improve outcomes from this potentially devastating public health problem.
Authors:
Michael Lewis; Parviz Ghassemi; Joseph Hibbeln
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-03
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  31     ISSN:  1532-8171     ISO Abbreviation:  Am J Emerg Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-03-14     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273.e5-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Brain Health Education and Research Foundation, Arlington, VA, USA. dr.michael.lewis@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Accidents, Traffic
Adolescent
Brain Injuries / diagnosis,  drug therapy*,  etiology,  surgery
Combined Modality Therapy
Craniotomy
Fatty Acids, Omega-3 / therapeutic use*
Gastrostomy
Humans
Magnetic Resonance Imaging
Male
Tomography, X-Ray Computed
Tracheotomy
Grant Support
ID/Acronym/Agency:
ZIA AA000115-12/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3
Comments/Corrections

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