Document Detail

Therapeutic ultrasound in cardiology.
MedLine Citation:
PMID:  12096656     Owner:  NLM     Status:  MEDLINE    
Ultrasound can be exploited to derive therapeutic results by using its bioeffects such as creation of mechanical vibrations, localized cavitations, microstream formation, physicochemical changes and thermal energy. Extensive in vitro and animal investigations during the last 2 decades have laid a foundation for ultrasound energy to be used for treatment purposes in various medical specialties. In the area of cardiovascular diseases, ultrasound could be used for thrombolysis, adjunct to coronary interventions, drug delivery, local gene transfer, and creating therapeutic lesions. The dispensation approaches to therapeutic ultrasound are varied, from the use of low- to medium-range frequency, low to focused high intensity, and catheter-based to external devices. Catheter-based ultrasound could be useful for intracoronary thrombolysis, and external ultrasound instrument with transcutaneous delivery could be of use in applications such as creation of myocardial lesions, peripheral vessel thrombolysis, and drug and gene delivery. Adjunct administration of microbubbles has been found to enhance thrombolysis, and drug and gene therapy. Ongoing studies strongly suggest that therapeutic ultrasound could have an important role in cardiovascular disorders associated with thrombosis, inflammation, atherosclerotic disease, and arrhythmias.
H Joachim Nesser; Darshak H Karia; Wolfgang Tkalec; Natesa G Pandian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Herz     Volume:  27     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-04     Completed Date:  2002-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  269-78     Citation Subset:  IM    
Department of Medicine, St. Elisabethinen Hospital, Linz, Austria.
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MeSH Terms
Cardiovascular Diseases / therapy*
Coronary Disease / therapy
Equipment Design
Gene Therapy / instrumentation
Lithotripsy / instrumentation
Thrombolytic Therapy / instrumentation
Ultrasonic Therapy / instrumentation*

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