| Therapeutic trials in nonalcoholic steatohepatitis: insulin sensitizers and related methodological issues. | |
| | |
MedLine Citation:
|
PMID: 21105109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Insulin sensitizers are attractive candidate therapies for nonalcoholic steatohepatitis mainly because of the strong association between this disease and insulin resistance. This review provides a critical overview of the mechanisms of action, clinical trial results, and safety issues of metformin and glitazones in nonalcoholic steatohepatitis. It also highlights methodological challenges for trial design and proposes endpoints for future proof of principle, registrational, and postmarketing trials. |
| | |
Authors:
|
Vlad Ratziu; Stephen Caldwell; Brent A Neuschwander-Tetri |
Related Documents
:
|
18945509 - Risk of coronary artery disease associated with initial sulphonylurea treatment of pati... 17728849 - Pioglitazone hydrochloride/glimepiride. 17258489 - Antidiabetic agents in subjects with mild dysglycaemia: prevention or early treatment o... 10789389 - The thiazolidinediones: a new class of antidiabetic agents. 18726829 - Efficacy and safety of vildagliptin monotherapy during 2-year treatment of drug-naïve ... 18458139 - Is the combination of sulfonylureas and metformin associated with an increased risk of ... 18024949 - Blood glucose and cerebrovascular disease in nondiabetic patients. 12021149 - The lymphocyte as a cellular model to study insights into the pathophysiology of diabet... 2337999 - Transient hyperglycemia during abdominal aortic surgery. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Hepatology (Baltimore, Md.) Volume: 52 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2011-01-10 Revised Date: 2011-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
|
Languages: eng Pagination: 2206-15 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 American Association for the Study of Liver Diseases. |
Affiliation:
|
Université Pierre et Marie Curie, Assistance Publique Hôpitaux de Paris, Hôpital Pitié Salpêtrière, INSERM UMRS 893 Paris, France. vratziu@teaser.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Clinical Trials as Topic Fatty Liver / diet therapy, drug therapy* Humans Hypoglycemic Agents / therapeutic use* Insulin / therapeutic use* Insulin Resistance / physiology Metformin / adverse effects, therapeutic use* Thiazolidinediones / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Hypoglycemic Agents; 0/Thiazolidinediones; 11061-68-0/Insulin; 657-24-9/Metformin |
| Comments/Corrections | |
Comment In:
|
Hepatology. 2011 Apr;53(4):1404-5; author reply 1405
[PMID:
21480350
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Critical role of the liver in the induction of systemic inflammation in rats with preascitic cirrhos...
Next Document: Sunitinib rechallenge in metastatic renal cell carcinoma patients.