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Therapeutic time window of YGY-E neuroprotection of cerebral ischemic injury in rats.
MedLine Citation:
PMID:  22466144     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
YGY-E is an active ingredient in traditional Chinese medical herbs which have anti-ischemic activity. The present work was designed to study its therapeutic time window in cerebral ischemic injury as well as its effect on neuronal apoptosis. Animals received an intravenous injection of YGY-E at 1, 3, and 6 h, respectively, after permanent focal cerebral ischemia induced by electrocoagulation of the middle cerebral artery. Infarct ratio and neurological function were employed to assess the effects of YGY-E on the therapeutic time window in this animal model. Furthermore, we evaluated effects of this compound on neuronal apoptosis and synthesis of Bcl-2 and Bax in ischemic brain tissue with in situ DNA end labeling (TUNEL), immunohistochemistry assay, and Western blot analysis. YGY-E (2-8 mg/kg) delivered at all the three time points dosedependently decreased infarct ratio, neurological deficits, percentage of TUNEL-positive cells (p < 0.01) and Bax-positive cells (p < 0.01 or p < 0.05). In contrast, it increased the percentage of Bcl-2 positive cells (p < 0.01 or p < 0.05). These data demonstrated that YGY-E had protective effects against cerebral ischemia injuries in rats. But more importantly, they indicate that YGY-E has an unusually long (up to 6 h) therapeutic time window relative to classical drugs in treating cerebral ischemia. In addition, our results suggest that the anti-apoptotic effects of YGY-E are due to its regulation of the balance between Bcl-2 and Bax protein levels.
Authors:
Y T An; Z Zhao; Y C Sheng; Y Min; Y Y Xia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug discoveries & therapeutics     Volume:  5     ISSN:  1881-7831     ISO Abbreviation:  Drug Discov Ther     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101493809     Medline TA:  Drug Discov Ther     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  76-83     Citation Subset:  -    
Affiliation:
Shanghai Institute of Pharmaceutical Industry, Shanghai, China.
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