| Therapeutic targeting of NF-κB in myelodysplastic syndromes and acute myeloid leukaemia - the biological heterogeneity. | |
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MedLine Citation:
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PMID: 20942744 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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NF-κB usually has antiapotptic effects and is involved in regulation of cell proliferation and intercellular communication. This is also true for the malignant cells in acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS), including the malignant stem cells. However, both AML and MDS patients are heterogeneous with regard to the effect of pharmacological NF-κB inhibition, and the final effect will probably also depend on the pharmacological agent used for the inhibition, e.g. proteasomal inhibitiors versus specific inhibitors. Even though initial studies suggest that NF-κB inhibitors have antileukemic effects, their future clinical use will also depend on their toxicity profile. |
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Authors:
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Øystein Bruserud; Håkon Reikvam |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on therapeutic targets Volume: 14 ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: England |
Other Details:
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Languages: eng Pagination: 1139-42 Citation Subset: IM |
Affiliation:
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University of Bergen, Institute of Internal Medicine, Norway. oystein.bruserud@haukeland.no |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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