| Therapeutic strategy of nephrotic syndrome in patients over eighty. | |
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MedLine Citation:
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PMID: 7933665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present paper, we report four very elderly patients (80 years of age or older) with primary nephrotic syndrome. In all patients, oral prednisolone (PSL) alternative day therapy was attempted and three patients responded very well (complete remission 2, partial remission 1). However, one patient exhibited no effect of PSL and died from acute oliguric renal failure in spite of aggressive measures including hemodialysis. Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain. In addition to our reported cases, 5 cases of nephrotic syndrome in similar patients reported elsewhere are analyzed together with our cohort. PSL was commonly effective in inducing remission in very elderly patients (7 of 9 patients; 78%). Very elderly patients with nephrotic syndrome frequently suffer from oliguric renal failure, which has a potentially high mortality. Based on these data, we conclude that PSL therapy can ameliorate primary nephrotic syndrome in patients over the age of eighty years. However, the complications both of the disease and its treatment, (e.g., acute oliguric renal failure, hip fracture) must be carefully monitored. |
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Authors:
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E Noiri; T Okuda; T Takano; K Kurokawa |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Nihon Jinzo Gakkai shi Volume: 36 ISSN: 0385-2385 ISO Abbreviation: Nihon Jinzo Gakkai Shi Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-11-22 Completed Date: 1994-11-22 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7505731 Medline TA: Nihon Jinzo Gakkai Shi Country: JAPAN |
Other Details:
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Languages: eng Pagination: 902-6 Citation Subset: IM |
Affiliation:
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Showa General Hospital Division of Nephrology, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Kidney Injury
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chemically induced Administration, Oral Aged Aged, 80 and over Female Femoral Neck Fractures / chemically induced Humans Male Nephrotic Syndrome / drug therapy* Prednisolone / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
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50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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