| Therapeutic strategy of late cerebral radionecrosis. A retrospective study of 21 cases. | |
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MedLine Citation:
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PMID: 20436395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Late cerebral radiation necrosis (LCR) is a serious complication of radiation treatment for brain tumors. This study investigates the diagnosis and management of patients with late clinical and neuroradiological cerebral radionecrosis after primary removal of brain neoplasm. The authors discuss the clinical features and long-term outcome of 21 patients with late cerebral radionecrosis and emphasize the importance of surgical and medical therapy. METHODS: Twenty-one patients with brain tumor treated by surgical resection or brain biopsy alone after radiotherapy during follow-up developed radionecrosis. The magnetic resonance imaging (MRI), surgical and clinical findings of these patients with radionecrosis are reviewed. RESULTS: MRI showed radionecrosis in 21 patients, 9 of which had undergone craniotomy for lesion removal. CONCLUSION: Late radionecrosis is infrequent following radiation therapy and may simulate tumor recurrence on MRI scans. From the authors' experience it is evident that, once begun, radiation treatment of neoplastic lesions can lead to complications such as late cerebral radionecrosis which often require surgical treatment. As correct diagnosis is necessary for appropriate treatment, a fair balance needs to be struck when considering ionizing radiation, medical therapy, surgery and diagnostic imaging. |
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Authors:
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B Carangelo; A Cerillo; A Mariottini; G Peri; G Rubino; V Mourmouras; L Palma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgical sciences Volume: 54 ISSN: 0390-5616 ISO Abbreviation: J Neurosurg Sci Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0432557 Medline TA: J Neurosurg Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 21-8 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of Siena, Siena, Italy. biagiorobicarangelo@gmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biopsy Brain Neoplasms / pathology*, radiotherapy*, surgery Craniotomy Diagnosis, Differential Female Follow-Up Studies Humans Magnetic Resonance Imaging Male Middle Aged Necrosis Neoplasm Recurrence, Local / pathology Neoplasms, Radiation-Induced / pathology*, surgery Postoperative Period Radiation Injuries / pathology* Radiotherapy / adverse effects* |
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