| Therapeutic strategies for nonmotor symptoms in early Parkinson's disease: the case for a higher priority and stronger evidence. | |
| | |
MedLine Citation:
|
PMID: 22166405 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
It is now recognized that the neuropathology of early Parkinson's disease (PD) is not limited to the nigrostriatal dopaminergic system, but also involves various brainstem nuclei, the hypothalamus, the olfactory system, and the peripheral autonomic nervous system. Given the disseminated neuropathology of early PD, the earliest clinical signs include a myriad of non-motor manifestations including sleep-wake cycle regulation, cognition, mood and motivation, olfactory and gustatory functions, autonomic functions, and sensory and pain processing. Despite this realization, there is clearly a paucity of trials that have systematically evaluated the treatment of non-motor symptoms of PD in the early stages. For example, only one largescale, placebo-controlled randomized trial has been conducted on the treatment of depression in PD patients. There are no reports of randomized controlled trials of therapeutic agents looking at the frequently reported anxiety and fatigue in early PD patients. Based on this lack of evidence, therapy for early non-motor manifestations is often ignored and the focus remains on dopamine replacement strategies with main outcomes being restricted to motor measurements, such as the Unified Parkinson's Disease Rating Scale. This article presents the case for prioritizing well-designed, controlled clinical trials of therapeutic interventions focusing on non-motor symptoms in early PD patients. |
| | |
Authors:
|
Roongroj Bhidayasiri; Daniel D Truong |
Related Documents
:
|
1103575 - Pipamperone (dipiperon, r3345) in troublesome mental retardates: a double-blind placebo... 12515335 - Influence of length of stay on patient satisfaction with hospital care in japan. 12395025 - Psychometric properties of the sf-12 (hebrew version) in a primary care population in i... 2387795 - Properties of the inventory to diagnose depression in american indian adolescents. 7443365 - Anxiety reduction in hospitalized schizophrenics through thermal biofeedback and relaxa... 10422615 - Prognostic factors and treatment-related changes associated with return to work in the ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Parkinsonism & related disorders Volume: 18 Suppl 1 ISSN: 1873-5126 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
|
Languages: eng Pagination: S110-3 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Chulalongkorn Center of Excellence on Parkinson's Disease and Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, 10330, Thailand; Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles 90095, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vaccination for Parkinson's disease.
Next Document: Rehabilitation, exercise therapy and music in patients with Parkinson's disease: a meta-analysis of ...