Document Detail


Therapeutic role of granulocyte transfusions.
MedLine Citation:
PMID:  3890096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granulocyte transfusions are used as adjuvant therapy for infection in neutropenic patients with underlying neoplastic disease, neutropenic infants, and patients with qualitative white blood cell disorders. In addition, prophylactic leukocyte transfusions have been administered to patients during remission induction for acute leukemia or after bone marrow transplantation. The role of granulocyte therapy will need constant reassessment as new antibiotics and other forms of treatment are developed. At present, granulocyte transfusions are indicated in the treatment of severely neutropenic patients with documented bacterial infection who are unlikely to recover hematopoietic function over the next week and are deteriorating despite 48-72 hr of optimal antibiotic therapy. Under these conditions, they improve the rate of survival from the infectious episode without clearly affecting the longer-term survival of the patient. Only a small minority of neutropenic patients will require granulocyte transfusions.
Authors:
M J DiNubile
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  7     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1985 Mar-Apr
Date Detail:
Created Date:  1985-06-25     Completed Date:  1985-06-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Agranulocytosis / complications*,  therapy
Anemia, Aplastic / complications
Bacterial Infections / complications,  therapy*
Blood Transfusion*
Centrifugation
Granulocytes / transplantation*
Humans
Leukapheresis / adverse effects
Leukemia / complications
Neutropenia / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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