| Therapeutic role of granulocyte transfusions. | |
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MedLine Citation:
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PMID: 3890096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Granulocyte transfusions are used as adjuvant therapy for infection in neutropenic patients with underlying neoplastic disease, neutropenic infants, and patients with qualitative white blood cell disorders. In addition, prophylactic leukocyte transfusions have been administered to patients during remission induction for acute leukemia or after bone marrow transplantation. The role of granulocyte therapy will need constant reassessment as new antibiotics and other forms of treatment are developed. At present, granulocyte transfusions are indicated in the treatment of severely neutropenic patients with documented bacterial infection who are unlikely to recover hematopoietic function over the next week and are deteriorating despite 48-72 hr of optimal antibiotic therapy. Under these conditions, they improve the rate of survival from the infectious episode without clearly affecting the longer-term survival of the patient. Only a small minority of neutropenic patients will require granulocyte transfusions. |
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Authors:
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M J DiNubile |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews of infectious diseases Volume: 7 ISSN: 0162-0886 ISO Abbreviation: Rev. Infect. Dis. Publication Date: 1985 Mar-Apr |
Date Detail:
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Created Date: 1985-06-25 Completed Date: 1985-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7905878 Medline TA: Rev Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 232-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Agranulocytosis / complications*, therapy Anemia, Aplastic / complications Bacterial Infections / complications, therapy* Blood Transfusion* Centrifugation Granulocytes / transplantation* Humans Leukapheresis / adverse effects Leukemia / complications Neutropenia / complications* |
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