Document Detail


Therapeutic review. Cardiac effects of atropine in man: an update.
MedLine Citation:
PMID:  2684867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of atropine in cardiovascular disorders is mainly in the management of patients with bradycardia. Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart. Recent observations that atropine in low doses results in paradoxical effects at the sinoatrial node (vagotonic) and the atrioventricular node (vagolytic) have lead to a concern for its safety in patients with acute myocardial infarction and bradycardia. This review discusses the basic cardiovascular pharmacology of the atropine, explores the mechanisms responsible for its paradoxical effects and discusses the clinical implications of these observations.
Authors:
G Das
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  27     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-01-04     Completed Date:  1990-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Affiliation:
UND School of Medicine, Fargo 58102.
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MeSH Terms
Descriptor/Qualifier:
Atropine / therapeutic use*
Heart / drug effects*
Heart Diseases / drug therapy*,  physiopathology
Humans
Chemical
Reg. No./Substance:
51-55-8/Atropine

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