Document Detail


Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance.
MedLine Citation:
PMID:  23447417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: These results suggest that recovery of HBV-impaired hepatocyte-intrinsic innate immunity by the dually functional vector might overcome systemic adaptive immunotolerance in an IFN-α- and TLR7-dependent manner. The strategy holds promise for therapeutic intervention of chronic persistent virus infection and associated cancers.
Authors:
Peixiang Lan; Cai Zhang; Qiuju Han; Jian Zhang; Zhigang Tian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-23
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
CD8-Positive T-Lymphocytes / immunology*
Genetic Vectors / immunology
Hep G2 Cells
Hepatitis B Antibodies / immunology
Hepatitis B Surface Antigens / blood,  immunology
Hepatitis B virus / immunology*
Hepatitis B, Chronic / immunology*
Hepatocytes / virology*
Humans
Immune Tolerance / immunology*
Immunity, Innate / immunology
Interferon Type I / antagonists & inhibitors
Membrane Glycoproteins / physiology
Mice
RNA, Small Interfering / genetics,  therapeutic use
Toll-Like Receptor 7 / physiology
Virus Replication / drug effects
Chemical
Reg. No./Substance:
0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens; 0/Interferon Type I; 0/Membrane Glycoproteins; 0/RNA, Small Interfering; 0/Tlr7 protein, mouse; 0/Toll-Like Receptor 7

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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