Document Detail


Therapeutic reactive oxygen generation.
MedLine Citation:
PMID:  18564617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An increase of the intracellular reactive oxygen species (ROS) concentration leads to the development of oxidative stress and, thus, to the damage of cell components. The cause-and-effect relations between these processes have not been fully established yet. The ability of photo excited supramolecular composites containing fullerenes C60 immobilized at nanosilica particles to generate reactive oxygen species (ROS) in cells of two types (rat thymocytes, and transformed cells of ascite Erlich carcinoma, EAC, and leucosis L1210) is demonstrated. The damaging effect of photo excited C60-composites are shown, which appeared to be selective and manifested in transformed cells, but not in thymocytes. It has been shown that after the irradiation of aqueous solutions or cell suspensions in the presence of fullerene C60, the generation of reactive oxygen species is observed. It has been shown that the influence of photo excited fullerene C60 on metabolic processes depends on the composition of C60-containing complex and on the type of the cells. The damaging effects of photo excited fullerene C60-containing composites were demonstrated to be selective. The data presented suggest that the application of fullerene C60-containing composites for the selective activation of ROS-dependent death program in certain types of tumor cells is very promising.
Authors:
Peter Scharff; Uwe Ritter; Olga P Matyshevska; Svitlana V Prylutska; Iryna I Grynyuk; Alexandr A Golub; Yuriy I Prylutskyy; Anatoliy P Burlaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tumori     Volume:  94     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-07-02     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Affiliation:
Technische Universität Ilmenau, Institute of Physics, Ilmenau, Germany. peter.scharff@tu-ilmenau.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / pharmacology*,  therapeutic use
Carcinoma, Ehrlich Tumor / drug therapy
Cell Survival / drug effects*
Fullerenes / pharmacology*,  therapeutic use
Leukemia L1210 / drug therapy
Nanocomposites*
Neoplasms / drug therapy*,  pathology,  radiotherapy
Photochemotherapy / methods*
Rats
Rats, Wistar
Reactive Oxygen Species / pharmacology*,  therapeutic use
Silicon Dioxide
Thymus Gland / cytology*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Fullerenes; 0/Reactive Oxygen Species; 7631-86-9/Silicon Dioxide; 99685-96-8/fullerene C60

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