Document Detail


Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms.
MedLine Citation:
PMID:  22332099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies beginning in the 1990s have reported that intake of quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is inversely related to cardiovascular disease. More recent work using hypertensive animals and humans (>140 mm Hg systolic and >90 mm Hg diastolic) indicates a decrease in blood pressure after quercetin supplementation. A number of proposed mechanisms may be responsible for the observed blood pressure decrease such as antioxidant effects, inhibition of angiotensin-converting enzyme activity, and improved endothelium-dependent and -independent function. The majority of these mechanisms have been identified using animal models treated with quercetin, and relatively few have been corroborated in human studies. The purpose of this review is to examine the evidence supporting the role of quercetin as a potential therapeutic agent and the mechanisms by which quercetin might exert its blood pressure-lowering effect.
Authors:
Abigail J Larson; J David Symons; Thunder Jalili
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-05
Journal Detail:
Title:  Advances in nutrition (Bethesda, Md.)     Volume:  3     ISSN:  2156-5376     ISO Abbreviation:  Adv Nutr     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-06-14     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101540874     Medline TA:  Adv Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Affiliation:
Department of Nutrition, Exercise, and Health Science, Central Washington University, Ellensburg, WA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology,  therapeutic use*
Blood Pressure / drug effects*
Flavonoids / pharmacology,  therapeutic use*
Humans
Hypertension / drug therapy*
Quercetin / pharmacology,  therapeutic use*
Grant Support
ID/Acronym/Agency:
R15 HL 091493-01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Flavonoids; 117-39-5/Quercetin
Comments/Corrections

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