Document Detail


Therapeutic potential of a polymer-encapsulated L-DOPA and dopamine-producing cell line in rodent and primate models of Parkinson's disease.
MedLine Citation:
PMID:  9588598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Encapsulation of cells within polymer membranes prior to transplantation provides a novel means of achieving continuous, site-specific delivery of therapeutic molecules to the CNS. The use of encapsulated dopamine-secreting cells that can be transplanted directly into the striatum has particular appeal for the treatment of Parkinson's disease. This article provides a brief and timely review of the progress that has been made over the past decade using encapsulated PC12 cells as a means of delivering dopamine and L-DOPA to the striatum in rodent and primate models of Parkinson's disease. The polymer membranes are well tolerated and biocompatible. Encapsulated PC12 cells survive in vivo for up to 6 mo, they release dopamine into the surrounding host striatum, and they clearly improve behavioral function in both dopamine-depleted rodents and primates. Although these results are promising, fundamental issues remain concerning the extent of dopamine diffusion from the polymer membranes and the number of devices needed for behavioral improvement, and the duration and consistency of cell viability and device output. Nevertheless, this technology appears to be a promising means of avoiding many of the practical, societal, and ethical issues that have been associated with other transplantation approaches.
Authors:
M D Lindner; D F Emerich
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Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  Cell transplantation     Volume:  7     ISSN:  0963-6897     ISO Abbreviation:  Cell Transplant     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-07-10     Completed Date:  1998-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-74     Citation Subset:  IM    
Affiliation:
CytoTherapeutics Inc., Lincoln, RI 02865, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotechnology
Cell Transplantation
Corpus Striatum
Diffusion Chambers, Culture
Disease Models, Animal
Dopamine / administration & dosage*,  biosynthesis*
Drug Delivery Systems
Humans
Levodopa / administration & dosage*,  biosynthesis*
PC12 Cells
Parkinson Disease / drug therapy*,  physiopathology,  therapy*
Polymers
Primates
Rats
Chemical
Reg. No./Substance:
0/Levodopa; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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