Document Detail


Therapeutic potential of peroxisome proliferator-activated receptors in chronic inflammation and colorectal cancer.
MedLine Citation:
PMID:  20951925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peroxisome proliferatoreactivated receptors (PPARs) are members of the nuclear hormone receptor superfamily and have been implicated in a variety of physiologic and pathologic processes, such as nutrient metabolism, energy homeostasis, inflammation, and cancer. This article highlights breakthroughs in our understanding of the potential roles of PPARs in inflammatory bowel disease and colorectal cancer. PPARs might hold the key to some of the questions that are pertinent to the pathophysiology of inflammatory diseases and colorectal cancer and could possibly serve as drug targets for new antiinflammatory therapeutic and anticancer agents.
Authors:
Dingzhi Wang; Raymond N DuBois
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Gastroenterology clinics of North America     Volume:  39     ISSN:  1558-1942     ISO Abbreviation:  Gastroenterol. Clin. North Am.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-04     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8706257     Medline TA:  Gastroenterol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  697-707     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chronic Disease
Colorectal Neoplasms / drug therapy*,  metabolism*,  prevention & control
Disease Progression
Humans
Inflammation / drug therapy*
Inflammatory Bowel Diseases / drug therapy,  prevention & control
Mice
Peroxisome Proliferator-Activated Receptors / agonists*,  genetics,  metabolism*
Rats
Grant Support
ID/Acronym/Agency:
P01 CA077839/CA/NCI NIH HHS; P01 CA077839-10/CA/NCI NIH HHS; P01-CA-77839/CA/NCI NIH HHS; P30 CA068485/CA/NCI NIH HHS; P30 CA068485/CA/NCI NIH HHS; P30 CA068485-10S1/CA/NCI NIH HHS; R01 DK062112/DK/NIDDK NIH HHS; R01 DK062112-10/DK/NIDDK NIH HHS; R01DK 62112/DK/NIDDK NIH HHS; R37 DK047297/DK/NIDDK NIH HHS; R37 DK047297-18/DK/NIDDK NIH HHS; R37-DK47297/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Peroxisome Proliferator-Activated Receptors
Comments/Corrections

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