Document Detail


Therapeutic potential of ghrelin in restricting-type anorexia nervosa.
MedLine Citation:
PMID:  22975066     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Anorexia nervosa (AN) is an eating disorder characterized by a decrease in caloric intake and malnutrition. It is associated with a variety of medical morbidities as well as significant mortality. Nutritional support is of paramount importance to prevent impaired quality of life later in life in affected patients. Some patients with restricting-type AN who are fully motivated to gain body weight cannot increase their food intake because of malnutrition-induced gastrointestinal dysfunction. Chronicity of AN prevents participation in social activities and leads to increased medical expenses. Therefore, there is a pressing need for effective appetite-stimulating therapies for patients with AN. Ghrelin is the only orexigenic hormone that can be given intravenously. Intravenous infusion of ghrelin is reported to increase food intake and body weight in healthy subjects as well as in patients with poor nutritional status. Here, we introduce the results of a pilot study that investigated the effects of ghrelin on appetite, energy intake, and nutritional parameters in five patients with restricting-type AN, who are fully motivated to gain body weight but could not increase their food intake because of malnutrition-induced gastrointestinal dysfunction.
Authors:
Mari Hotta; Rina Ohwada; Takashi Akamizu; Tamotsu Shibasaki; Kenji Kangawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  514     ISSN:  1557-7988     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-98     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Health Services Center, National Graduate Institute for Policy Studies, Tokyo, Japan; Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: marihs@grips.ac.jp.
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