| Therapeutic potential of gastric electrical stimulation for obesity and its possible mechanisms: a preliminary canine study. | |
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MedLine Citation:
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PMID: 12741458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our aim was to investigate the effects of gastric electrical stimulation on food intake, weight, gastric myoelectrical, and parasympathetic activity. Dogs were implanted with serosal electrodes and a subcutaneous stimulator. The stimulator was turned on and off alternately every month for 4 months. Food intake, weight, gastric myoelectrical activity, and electrocardiograms were recorded. Daily food intake and weight were significantly decreased during the months with stimulation. Stimulation did not show any acute effect on gastric myoelectrical activity; however, it chronically and significantly impaired gastric myoelectrical activity in the fed state, but not in the fasting state. The parasympathetic activity in the fasting state assessed from the spectral analysis of heart rate variability was markedly decreased with stimulation both acutely and chronically. In conclusion, chronic gastric electrical stimulation results in a reduction in food intake, weight loss, a reduction in parasympathetic activity, and chronic inhibition of gastric myoelectrical activity. These data suggest that gastric electrical stimulation is a potential therapy for the treatment of obesity and its inhibitory effect on food intake and weight may involve both muscles and the vagal afferent pathway. |
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Authors:
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Hui Ouyang; Jieyun Yin; J D Z Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 48 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-05-13 Completed Date: 2003-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 698-705 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Eating / physiology Electric Stimulation Therapy / instrumentation* Electrocardiography Electrodes, Implanted Female Gastric Emptying / physiology Heart Rate / physiology Myoelectric Complex, Migrating / physiology* Obesity / physiopathology, therapy* Parasympathetic Nervous System / physiology* Stomach / innervation* Weight Loss / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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