Document Detail


Therapeutic potential of decoy oligonucleotides strategy in cardiovascular diseases.
MedLine Citation:
PMID:  15030273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent progress in molecular biology has provided several new techniques to inhibit target gene expression. In particular, the application of DNA technology, such as an antisense strategy, to regulate the transcription of disease-related genes in vivo has important therapeutic potential. Recently, transfer of cis-element double-stranded oligonucleotides (ODN) (= decoy) has been reported as a new powerful tool in a new class of antigene strategies for gene therapy. Transfer of the double-stranded ODN corresponding to the cis-sequence will result in attenuation of the authentic cis-trans interaction, leading to removal of trans-factors from the endogenous cis-elements with subsequent modulation of gene expression.
Authors:
Naruya Tomita; Toshio Ogihara; Ryuichi Morishita
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  1     ISSN:  1477-9072     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-04-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-70     Citation Subset:  IM    
Affiliation:
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japan. tomita@hp-gm.med.osaka-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / therapy*
Gene Therapy*
Humans
Oligonucleotides / genetics*
Chemical
Reg. No./Substance:
0/Oligonucleotides

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