| Therapeutic potential of cholesteryl O-acyl α-glucoside found in Helicobacter pylori. | |
| | |
MedLine Citation:
|
PMID: 22934809 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Steryl glycosides are derivatives of sterols where the 3β-hydroxy group is glycosylated. Some of them are further converted to steryl O-acyl glycosides. Steryl glycosides and their derivatives are widely distributed in plants, algae, and fungi, but are relatively rarely distributed in bacteria and animals. Accumulating evidence suggests that glycosylation of sterols not only modifies physicochemical properties of cell membranes but also alters immunogenicity of the cells. Helicobacter pylori, that colonizes the stomach and causes gastric diseases, is auxotrophic for cholesterol, so that it extracts this lipid from plasma membranes of epithelial cells of the host stomach. Since incorporation of cholesterol promotes immune responses of the host, Helicobacter pylori converts cholesterol to cholesteryl glucoside (ChG) and then to cholesteryl 6'-O-acyl glucoside (ChAcG) to evade the immune surveillance. We have found that ChAcG thus produced is specifically recognized by invariant Vα14-Jα18 TCR+ (Vα14) NKT cells in a CD1-dependent manner. We have also found that activation of Vα14 NKT cells by administration of ChAcG retains homeostasis of immunity upon exposure to allergens and reduces the incidence of allergy. In this article, overview of immunological functions of steryl glycosides with an emphasis on the immunoregulatory functions of ChAcG, is demonstrated. |
| | |
Authors:
|
Michio Shimamura; Hiroshi Hidaka |
Related Documents
:
|
23332779 - Sensing the immune microenvironment to coordinate t cell metabolism, differentiation & ... 23269409 - Down-regulation of fas activity rescues early onset of diabetes in c-kitwv/+ mice. 23689639 - Irgm1 regulates oxidized ldl uptake by macrophage via actin-dependent receptor internal... 23397389 - Detection of necrosis by release of lactate dehydrogenase activity. 23132899 - Stichoposide c induces apoptosis through the generation of ceramide in leukemia and col... 23166749 - Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting map... 22580469 - Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. 16549049 - Antitumor activity and immune enhancement of murine interleukin-23 expressed in murine ... 8050189 - Systemic lupus erythematosus: theories of pathogenesis and approach to therapy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-27 |
Journal Detail:
|
Title: Current medicinal chemistry Volume: - ISSN: 1875-533X ISO Abbreviation: Curr. Med. Chem. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Tsukuba Research Center for Interdisciplinary Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. michio@chem.tsukuba.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Yersinia pestis and Approaches to Targeting its Outer Protein H Protein-Tyrosine Phosphatase (YopH).
Next Document: Development of Polyphenols as HIV-1 Integrase Inhibitors: A Summary and Perspective.