Document Detail

Therapeutic potential of cholesteryl O-acyl α-glucoside found in Helicobacter pylori.
MedLine Citation:
PMID:  22934809     Owner:  NLM     Status:  Publisher    
Steryl glycosides are derivatives of sterols where the 3β-hydroxy group is glycosylated. Some of them are further converted to steryl O-acyl glycosides. Steryl glycosides and their derivatives are widely distributed in plants, algae, and fungi, but are relatively rarely distributed in bacteria and animals. Accumulating evidence suggests that glycosylation of sterols not only modifies physicochemical properties of cell membranes but also alters immunogenicity of the cells. Helicobacter pylori, that colonizes the stomach and causes gastric diseases, is auxotrophic for cholesterol, so that it extracts this lipid from plasma membranes of epithelial cells of the host stomach. Since incorporation of cholesterol promotes immune responses of the host, Helicobacter pylori converts cholesterol to cholesteryl glucoside (ChG) and then to cholesteryl 6'-O-acyl glucoside (ChAcG) to evade the immune surveillance. We have found that ChAcG thus produced is specifically recognized by invariant Vα14-Jα18 TCR+ (Vα14) NKT cells in a CD1-dependent manner. We have also found that activation of Vα14 NKT cells by administration of ChAcG retains homeostasis of immunity upon exposure to allergens and reduces the incidence of allergy. In this article, overview of immunological functions of steryl glycosides with an emphasis on the immunoregulatory functions of ChAcG, is demonstrated.
Michio Shimamura; Hiroshi Hidaka
Related Documents :
24866269 - Structure and function of renal macrophages and dendritic cells from lupus-prone mice.
24351979 - Evaluation of innate immune responses in bovine forestomachs.
23548129 - Chemical characterization and in vivo anti-inflammatory activities of actinidia callosa...
23725669 - Recent insights into apicomplexan parasite egress provide new views to a kill.
21952919 - Rocaglamide and a xiap inhibitor cooperatively sensitize trail- mediated apoptosis in h...
23433459 - The yin and yang of protein kinase c-theta (pkcθ): a novel drug target for selective i...
20618959 - Differential and coordinated expression of defensins and cytokines by gingival epitheli...
17456759 - Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-in...
9694869 - Transcriptional activation of the p21(waf1,cip1,sdi1) gene by interleukin-6 type cytoki...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-27
Journal Detail:
Title:  Current medicinal chemistry     Volume:  -     ISSN:  1875-533X     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Tsukuba Research Center for Interdisciplinary Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Yersinia pestis and Approaches to Targeting its Outer Protein H Protein-Tyrosine Phosphatase (YopH).
Next Document:  Development of Polyphenols as HIV-1 Integrase Inhibitors: A Summary and Perspective.