Document Detail


Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions.
MedLine Citation:
PMID:  21602589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cepharanthine (CEP) is a naturally occurring alkaloid extracted from the plant Stephania cepharantha Hayata. It has been widely used in Japan for more than 40 years to treat a wide variety of acute and chronic diseases. CEP inhibits tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppresses cytokine production. It has also been shown to scavenge free radicals and to have a protective effect against some of the responses mediated by pro-inflammatory cytokines such as TNF-α, interleukin (IL)-1β and IL6. CEP has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported.
Authors:
Moshe Rogosnitzky; Rachel Danks
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  63     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-09-16     Revised Date:  2011-11-28    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  337-47     Citation Subset:  IM    
Affiliation:
MedInsight Research Institute, P.O. Box 386, Telz Stone, 90840, Israel. moshe@medinsight.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / adverse effects,  isolation & purification,  pharmacology
Antineoplastic Agents, Phytogenic / adverse effects,  isolation & purification,  pharmacology
Benzylisoquinolines / adverse effects,  isolation & purification,  pharmacology*
Humans
Japan
Medicine, East Asian Traditional
Stephania / chemistry*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antineoplastic Agents, Phytogenic; 0/Benzylisoquinolines; 481-49-2/cepharanthine

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