Document Detail

Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure.
MedLine Citation:
PMID:  23338054     Owner:  NLM     Status:  Publisher    
BACKGROUND: Exertional heat stroke (EHS) results in a constellation of systemic inflammatory responses resulting in multiorgan failure and an extremely high mortality. CASE DIAGNOSIS AND TREATMENTS: We present the case of an 11-year-old obese male who suffered EHS with rhabdomyolysis and concurrent renal, pulmonary, and hepatic failure. Conventional therapies including continuous veno-venous hemodiafiltration (CVVHDF) were ineffective in preventing ongoing deterioration in clinical status. Liver biopsy was reported as "extensive hepatocyte ballooning" and liver-kidney transplantation was tentatively planned. CONCLUSIONS: The addition of therapeutic plasma exchange using the Prismaflex® system (Gambro, Lakewood, CO, USA) resulted in a reversal of the inflammatory process and recovery from multiorgan failure. Liver biopsy was not a reliable indicator of irreversible hepatic injury.
Vimal Master Sankar Raj; Amanda Alladin; Brent Pfeiffer; Chryso Katsoufis; Marissa Defreitas; Alicia Edwards-Richards; Jayanthi Chandar; Wacharee Seeherunvong; Gwenn McLaughlin; Gaston Zilleruelo; Carolyn L Abitbol
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  -     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Division of Pediatric Nephrology (R-714), University of Miami/Holtz Children's Hospital at Jackson Health System, PO Box 016960, Miami, FL, 33101, USA.
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