Document Detail

Therapeutic plasma exchange in the treatment of neuroimmunologic disorders: review of 50 cases.
MedLine Citation:
PMID:  17224307     Owner:  NLM     Status:  MEDLINE    
Therapeutic plasma exchange (TPE) has been used for the treatment of neurologic diseases in which autoimmunity plays a major role. We reviewed the medical records of our patients who had consecutively been treated by TPE between January 1998 and June 2000. Neurological indications included myasthenia gravis (30 patients), multiple sclerosis attack (6 patients with remitting-relapsing course and 3 patients with secondary progressive course), Guillain-Barrè syndrome (6 patients), paraproteinemic neuropathy (2 patients), and chronic inflammatory demyelinating neuropathy (CIDP), transverse myelitis due to systemic lupus erythematosus, acute disseminated encephalomyelitis in one patient each. Continuous flow cell separators were used for TPE. TPE was generally given every other day for all of the patients and one plasma volume was exchanged for each cycle. Although the patients with secondary progressive multiple sclerosis (3 patients) and paraproteinemic neuropathy (2 patients) did not show any improvement after TPE, other patients' targeted neurological deficits were improved by TPE. During the TPE procedures, no patient had any morbidity or mortality, and the complications were mild and manageable such as hypotension, hypocalcemia and mild anemia; three patients had septicemia due to the venous catheter used for TPE. TPE is an effective treatment in neurologic diseases in which autoimmunity plays an important role in pathogenesis, and it is safe when performed in experienced centers.
Canan Yücesan; Onder Arslan; Mutlu Arat; Nezih Yücemen; Erol Ayyildiz; Osman Ilhan; Nermin Mutluer
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-01-16
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  36     ISSN:  1473-0502     ISO Abbreviation:  Transfus. Apher. Sci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-09     Completed Date:  2008-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  T    
Ankara University Faculty of Medicine, Ibni Sina Hospital, Department of Neurology, Sihhiye, 06100 Ankara, Turkey.
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MeSH Terms
Anemia / etiology,  therapy
Autoimmune Diseases of the Nervous System / complications,  therapy*
Hypocalcemia / etiology,  therapy
Hypotension / etiology,  therapy
Plasma Exchange* / adverse effects
Remission Induction
Retrospective Studies
Sepsis / etiology,  therapy

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