Document Detail


Therapeutic plasma exchange for acute inflammatory demyelinating syndromes of the central nervous system.
MedLine Citation:
PMID:  10540370     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Idiopathic inflammatory demyelinating diseases (IIDDs) of the central nervous system, of which multiple sclerosis is the prototype, represent a family of monophasic, recurrent or progressive diseases with overlapping clinical and pathological manifestations. While most patients recover spontaneously or following a brief course of high-dose corticosteroids, occasional patients, particularly those with fulminant severe IIDDs, such as the Marburg variant, do not respond to corticosteroids and have severe, residual neurological deficits. While it is widely believed that IIDDs are mediated by T lymphocytes, as is experimental allergic encephelomyelitis, additional, possibly humoral, factors may be essential to generate the extensive demyelination seen in these conditions. Anecdotal reports over the past two decades have suggested that patients with acute, severe neurological deficits resulting from IIDDs, who fail to improve after high-dose intravenous corticosteroids, may benefit from plasma exchange. A randomized, sham-controlled, crossover study has recently been completed at the Mayo Clinic, which addresses these observations.
Authors:
B G Weinshenker
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  14     ISSN:  0733-2459     ISO Abbreviation:  J Clin Apher     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-21     Completed Date:  1999-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Wiley-Liss, Inc.
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota 55902, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Central Nervous System Diseases / therapy*
Demyelinating Diseases / therapy*
Humans
Multiple Sclerosis / therapy*
Neuritis / therapy*
Plasma Exchange*
Randomized Controlled Trials as Topic
Syndrome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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