| Therapeutic plasma exchange for acute inflammatory demyelinating syndromes of the central nervous system. | |
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MedLine Citation:
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PMID: 10540370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic inflammatory demyelinating diseases (IIDDs) of the central nervous system, of which multiple sclerosis is the prototype, represent a family of monophasic, recurrent or progressive diseases with overlapping clinical and pathological manifestations. While most patients recover spontaneously or following a brief course of high-dose corticosteroids, occasional patients, particularly those with fulminant severe IIDDs, such as the Marburg variant, do not respond to corticosteroids and have severe, residual neurological deficits. While it is widely believed that IIDDs are mediated by T lymphocytes, as is experimental allergic encephelomyelitis, additional, possibly humoral, factors may be essential to generate the extensive demyelination seen in these conditions. Anecdotal reports over the past two decades have suggested that patients with acute, severe neurological deficits resulting from IIDDs, who fail to improve after high-dose intravenous corticosteroids, may benefit from plasma exchange. A randomized, sham-controlled, crossover study has recently been completed at the Mayo Clinic, which addresses these observations. |
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Authors:
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B G Weinshenker |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical apheresis Volume: 14 ISSN: 0733-2459 ISO Abbreviation: J Clin Apher Publication Date: 1999 |
Date Detail:
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Created Date: 1999-12-21 Completed Date: 1999-12-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 144-8 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Wiley-Liss, Inc. |
Affiliation:
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Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota 55902, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Central Nervous System Diseases / therapy* Demyelinating Diseases / therapy* Humans Multiple Sclerosis / therapy* Neuritis / therapy* Plasma Exchange* Randomized Controlled Trials as Topic Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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