| Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase. | |
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MedLine Citation:
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PMID: 21356170 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Currently, light therapies are widely used in both human and veterinarian medicine. The application of light to clinical therapeutics includes: photodynamic therapy, used to kill cancer cells; UVA therapies, used to treat a variety of skin diseases; and photobiomodulation, used to promote cell growth and recovery from injury. Photobiomodu-lation uses light emitting diodes (LEDs) or low energy lasers, which emit light in the visible red to near infrared range. Light in this range penetrates tissue reasonably well, lacks the carcinogenic/mutagenic properties of UV light, and acts on an endogenous photoreceptor which likely acts to initiate light-altered signaling pathways. Although early studies identified mitochondrial cytochrome c oxidase as an endogenous photoreceptor for photobiomodulation, the cellular and molecular mechanisms underlying photobiomodulation have not been clear. Three recent findings provide important new insight. First, nitric oxide has been implicated. Second, cytochrome c oxidase, an enzyme known to reduce oxygen to water at the end of the mitochondrial respiratory chain, has been shown to have a new enzymatic activity - the reduction of nitrite to nitric oxide. This nitrite reductase activity is elevated under hypoxic conditions but also occurs under normoxia. And third, low intensity light enhances nitric oxide synthesis by cytochrome c oxidase without altering its ability to reduce oxygen. From these findings, we propose that cytochrome c oxidase functions in photobiomodulation by producing nitric oxide, a signaling molecule which can then function in both intra- and extracellular signaling pathways. We also propose that the effectiveness of photobiomodulation is under the control of tissue oxygen and nitrite levels. |
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Authors:
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Robert O Poyton; Kerri A Ball |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Discovery medicine Volume: 11 ISSN: 1944-7930 ISO Abbreviation: Discov Med Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101250006 Medline TA: Discov Med Country: United States |
Other Details:
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Languages: eng Pagination: 154-9 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA. robert.poyton@colorado.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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