Document Detail

Therapeutic neovascularization for coronary disease: current state and future prospects.
MedLine Citation:
PMID:  21713563     Owner:  NLM     Status:  Publisher    
Despite advances in surgical and percutaneous revascularization techniques, nearly one-third of patients with ischemic coronary artery disease are not candidates for revascularization due to suboptimal anatomy or receive suboptimal revascularization from these standard procedures. Neovascularization of the myocardium is not only a physiologic response to ischemia, but also potentially the target of new therapeutic strategies. Induced angiogenesis via protein, gene, and cell-based therapies showed initial promise in experiments using otherwise healthy laboratory animals. However, failure to translate these gains into humans prompted further study into the vascular environment and endothelial dysfunction. Understanding that factors such as hypertension, diabetes, and hyperlipidemia are not only placing patients at risk for coronary artery disease but also undermining our attempts in neovascularization therapies, has prompted us to rethink our therapeutic approach. Future directions for therapeutic neovascularization lie in therapies combining optimization of the vascular environment, improvement of endothelial function and other aspects of vascular formation and development.
Antonio D Lassaletta; Louis M Chu; Frank W Sellke
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-29
Journal Detail:
Title:  Basic research in cardiology     Volume:  -     ISSN:  1435-1803     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Surgery, Division of Cardiothoracic Surgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.
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