Document Detail

Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases.
MedLine Citation:
PMID:  19689348     Owner:  NLM     Status:  MEDLINE    
Vasculopathy in patients with connective tissue diseases (CTDs), including systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), is a serious complication that mainly affects small arteries and capillaries, reduces the blood flow and causes progressive tissue ischemia. Recently, CTD patients have been reported to have abnormalities in circulating endothelial progenitor cells (EPCs); these abnormalities are believed to contribute to the pathophysiology of vasculopathy and to the premature and accelerated development of atherosclerosis in CTD patients. Furthermore, we are currently conducting a clinical pilot study to determine the efficacy of implanting autologous mononuclear cells obtained from the bone marrow and peripheral blood into the ischemic digits or limbs of CTD patients. In this review, we discuss the role of EPCs in the process of neovascularization and in the pathophysiology of CTDs, and we describe a clinical pilot study on the use of autologous cell therapy for treating ischemic digits in patients with CTDs.
Masafumi Takahashi; Atsushi Izawa; Yoshiaki Ishigatsubo; Kazuteru Fujimoto; Masaaki Miyamoto; Takashi Horie; Yoshifusa Aizawa; Jun Amano; Seiji Minota; Toyoaki Murohara; Hiroaki Matsubara; Uichi Ikeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  15     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-19     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2778-83     Citation Subset:  IM    
Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine, Japan.
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MeSH Terms
Antigens, CD34 / analysis
Connective Tissue Diseases / physiopathology,  therapy*
Endothelial Cells / cytology
Extremities / blood supply
Ischemia / therapy
Leukocytes, Mononuclear / transplantation*
Neovascularization, Physiologic
Transplantation, Autologous
Reg. No./Substance:
0/Antigens, CD34

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