Document Detail


Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?
MedLine Citation:
PMID:  23199318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T cells reactive to lipids and restricted by major histocompatibility complex (MHC) class I-like molecules represent more than 15% of all lymphocytes in human blood. This heterogeneous population of innate cells includes the invariant natural killer T cells (iNK T), type II NK T cells, CD1a,b,c-restricted T cells and mucosal-associated invariant T (MAIT) cells. These populations are implicated in cancer, infection and autoimmunity. In this review, we focus on the role of these cells in autoimmunity. We summarize data obtained in humans and preclinical models of autoimmune diseases such as primary biliary cirrhosis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, psoriasis and atherosclerosis. We also discuss the promise of NK T cell manipulations: restoration of function, specific activation, depletion and the relevance of these treatments to human autoimmune diseases.
Authors:
Y Simoni; J Diana; L Ghazarian; L Beaudoin; A Lehuen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-19     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  8-19     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthritis, Rheumatoid / immunology
Atherosclerosis / immunology
Autoimmunity / immunology*
Clinical Trials, Phase I as Topic
Diabetes Mellitus, Type 1 / immunology
Female
Galactosylceramides / therapeutic use
Humans
Liver Cirrhosis, Biliary / immunology
Lupus Erythematosus, Systemic / immunology
Male
Mice
Multiple Sclerosis / immunology
Natural Killer T-Cells / drug effects,  immunology*
Psoriasis / immunology
Chemical
Reg. No./Substance:
0/Galactosylceramides; 0/alpha-galactosylceramide
Comments/Corrections

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