Document Detail

Therapeutic management of type 1 diabetes before and during pregnancy.
MedLine Citation:
PMID:  21329488     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Pregnancy increases the risks of adverse outcomes for mother and infant in women with type 1 diabetes. Obtaining and maintaining adequate glycemic control during pregnancy is crucial for optimizing outcomes.
AREAS COVERED: The importance of prepregnancy planning and treatment during pregnancy is reviewed. The use of insulin analogues and antihypertensive drugs in diabetic pregnancy are in focus. The reader is presented with evidence discussing the importance of prepregnancy counseling and treatment during pregnancy in women with type 1 diabetes.
EXPERT OPINION: Tight glycemic control before and during pregnancy is crucial and the prevalence of severe hypoglycemia during pregnancy needs to be reduced. Rapid-acting insulin analogues are regarded as safe to use in pregnancy and studies on long-acting insulin analogues are in the pipeline. Supplementation with folic acid may reduce the risk of malformations. Screening for diabetic retinopathy, diabetic nephropathy and thyroid dysfunction is important, and indications for antihypertensive treatment and treatment of thyroid dysfunction need to be in focus before and during pregnancy.
Elisabeth R Mathiesen; Lene Ringholm; Peter Damm
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-02-18
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  12     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-10     Completed Date:  2011-06-27     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  779-86     Citation Subset:  IM    
University of Copenhagen, Center for Pregnant Women with Diabetes, Department of Endocrinology and Obstetrics, Faculty of Health Science, 2132, Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark.
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MeSH Terms
Blood Glucose / analysis
Diabetes Mellitus, Type 1 / blood,  drug therapy*
Insulin / therapeutic use*
Pregnancy Outcome
Pregnancy in Diabetics*
Reg. No./Substance:
0/Blood Glucose; 0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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