Document Detail


Therapeutic management of hypertrophic obstructive cardiomyopathy: alcohol septal ablation or surgical myomectomy?
MedLine Citation:
PMID:  25039895     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypertrophic cardiomyopathy (HCM) is characterized as left ventricular hypertrophy unexplained by abnormal loading conditions. Approximately 30% of patients with HCM will develop left ventricular outflow obstruction under resting conditions. In the 5-10% of patients with drug-refractory symptoms, surgical septal myectomy has been shown to reduce outflow obstruction and relieve symptoms; however, some patients may be at increased risk for surgery. Since 1994, when alcohol septal ablation was introduced, an increasing number of patients have opted for the percutaneous approach, which aims to mimic the anatomic and hemodynamic effects of surgical septal myectomy. The less-invasive version of septal reduction therapy comes at a price: a larger number of pacemaker implantations and, sometimes, depending on the individual's coronary anatomy, a higher residual gradient. Despite these shortcomings and the absence of randomized trials, alcohol septal ablation has established itself as a viable option for patients with obstructive HCM.
Authors:
Stephane Noble; Ulrich Sigwart
Related Documents :
10335755 - Relation of qt dispersion to infarct size and left ventricular wall motion in anterior ...
10980225 - Common polymorphism in the promoter of the cd14 monocyte receptor gene is associated wi...
8205665 - Microvascular integrity indicates myocellular viability in patients with recent myocard...
1599655 - Ventricular remodeling following myocardial infarction: a description of the pathologic...
12042685 - Hemodynamic responses during aerobic and resistance exercise.
24881775 - Harnessing hippo in the heart: hippo/yap signaling and applications to heart regenerati...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-21
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  -     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-4     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apopt...
Next Document:  Enhanced Light-Harvesting Capacity by Micellar Assembly of Free Accessory Chromophores and LH1-like ...