Document Detail


Therapeutic management of fetal anemia: review of standard practice and alternative treatment options.
MedLine Citation:
PMID:  23093258     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Fetal anemia, mainly due to red cell alloimmunization, is still a significant cause of fetal and neonatal mortality and morbidity. The focus of current clinical research has shifted from an invasive approach to non-invasive management and treatment of affected pregnancies, and the progress in this field is associated with a major improvement in perinatal outcome. During the last 50 years, intrauterine red cells transfusion (IUT), first via the intraperitoneal route and later directly to fetal circulation, is the standard practice in most centers, with survival rates that exceed 90%, particularly if anemia is diagnosed early and treated in a timely manner. In addition, plasmapheresis and intravenous administration of high-dose immunoglobulin have been implicated in the treatment of pregnancies complicated with early-onset severe red cell alloimmunization, alone or in combination with IUTs before the 20th week of pregnancy, but there are still issues to be clarified further. This review article aims to provide an overview of the current standard therapeutic management and alternative treatment modalities in pregnancies complicated by fetal anemia.
Authors:
Nikos Papantoniou; Stavros Sifakis; Aris Antsaklis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-14
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  -     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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