| Therapeutic management of chronic venous insufficiency: microcirculation as a target. | |
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MedLine Citation:
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PMID: 11151967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic venous insufficiency, in its most severe manifestations as well as in its mild form, is linked to venous valve failure, weakness of the venous wall, and leukocyte-endothelial interactions all of which lead to cutaneous and subcutaneous tissue changes. These in turn are related to venous hypertension-induced leukocyte activation, which may provide a target for pharmacotherapeutic intervention. Currently, surgical attack is focused on correction of the sources of venous hypertension, but it is felt that this provides a crude method that hopefully wil be replaced by more precise pharmacological interventions. |
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Authors:
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J J Bergan; G W Schmid-Schönbein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 7 ISSN: 1073-9688 ISO Abbreviation: Microcirculation Publication Date: 2000 |
Date Detail:
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Created Date: 2001-01-09 Completed Date: 2001-03-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: S23-8 Citation Subset: IM |
Affiliation:
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University of California San Diego, La Jolla 92037, USA. jbergan@ucsd.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Adhesion Chronic Disease Endothelium, Vascular / metabolism Humans Hypertension / pathology, physiopathology Immunohistochemistry Leukocytes / immunology Microcirculation / drug effects*, pathology, surgery Skin / pathology Veins / pathology, physiopathology Venous Insufficiency / blood*, drug therapy*, physiopathology, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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