| Therapeutic management of bacterial meningitis in children: a systematic review and comparison of published guidelines from a European perspective. | |
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MedLine Citation:
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PMID: 20685625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial meningitis is an infectious disease emergency that can cause substantial morbidity and mortality. We compared the most recent international guidelines and recommendations on bacterial meningitis management in infants and children in developed countries, in terms of initial management approach, empirical antimicrobial therapy, timing, dosages, and duration of antimicrobial therapy, and possible adjunctive treatment with dexamethasone. Secondly, epidemiological data on bacterial resistance in several european countries were analyzed and discussed in relation to the therapies currently recommended for bacterial meningitis. The comparative analysis of the selected guidelines highlighted significant differences in the therapeutic management of bacterial meningitis. Differences among guidelines have important consequences for daily practice. An agreed protocol for early, evidence-based, and effective therapeutic management of bacterial meningitis is essential for the best outcome. further studies and expert consensus are required to establish the best management of bacterial meningitis in the european setting based on the most recent epidemiological data on resistance rates. |
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Authors:
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M DE Gaudio; E Chiappini; L Galli; M DE Martino |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Journal of chemotherapy (Florence, Italy) Volume: 22 ISSN: 1973-9478 ISO Abbreviation: J Chemother Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907348 Medline TA: J Chemother Country: Italy |
Other Details:
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Languages: eng Pagination: 226-37 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Florence, Florence, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Anti-Bacterial Agents / therapeutic use* Child Child, Preschool Clinical Trials as Topic Dexamethasone / therapeutic use Drug Resistance, Microbial Europe Guidelines as Topic* Humans Infant Infant, Newborn Meningitis, Bacterial / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Bacterial Agents; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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