Document Detail


Therapeutic implications of the enhanced short and long-term cytotoxicity of radiation treatment followed by oncolytic parvovirus H-1 infection in high-grade glioma cells.
MedLine Citation:
PMID:  21468212     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prognosis of malignant brain tumors remains extremely bad in spite of moderate improvements of conventional treatments. A promising alternative approach is the use of oncolytic viruses. Strategies to improve viral toxicity include the combination of oncolytic viruses with standard therapies. Parvovirus H-1 (H-1PV) is an oncolytic virus with proven toxicity in glioma cells. Recently it has been demonstrated that the combination of ionizing radiation (IR) with H-1PV showed promising results. Previously irradiated glioma cells remained fully permissive for H-1PV induced cytotoxicity supporting the use of H-1PV for recurrent gliomas, which typically arise from irradiated cell clones. When glioma cells were infected with H-1PV shortly (24 h) after IR, cell killing improved and only the combination of both treatments lead to complete long-term tumor cell killing. The latter finding raises the question whether IR in combination with H-1PV exerts an additional therapeutic effect on highly resistant glioma stem cells. A likely translation into current clinical treatment protocols is to use stereotactic radiation of non-resectable recurrent gliomas followed by intratumoral injection of H-1PV to harvest the synergistic effects of combination treatment.
Authors:
Karsten Geletneky; Andreas D Hartkopf; Robert Krempien; Jean Rommelaere; Joerg R Schlehofer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioengineered bugs     Volume:  1     ISSN:  1949-1026     ISO Abbreviation:  Bioeng Bugs     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2011-07-28     Completed Date:  2011-10-17     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101525147     Medline TA:  Bioeng Bugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-33     Citation Subset:  IM    
Copyright Information:
© 2010 Landes Bioscience
Affiliation:
Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany. k.geletneky@dkfz.de
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / pathology,  radiotherapy*,  virology*
Cell Survival / radiation effects
Combined Modality Therapy
Glioma / pathology,  radiotherapy*,  virology*
H-1 parvovirus / physiology*
Humans
Oncolytic Virotherapy / methods*
Oncolytic Viruses / physiology
Tumor Cells, Cultured / radiation effects,  virology
Comments/Corrections

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