Document Detail

Therapeutic hypothermia and traumatic brain injury.
MedLine Citation:
PMID:  20090519     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Therapeutic hypothermia after traumatic brain injury (TBI)? For the last 10 years, no topic has been more popular and more controversial among neurointensivists. This article reviews the most current findings (experimental, clinical, adult and pediatric TBI), as well as the clinical management of therapeutic hypothermia. RECENT FINDINGS: Despite ample experimental evidence, the clinical utility of therapeutic hypothermia has still to be conclusively demonstrated in terms of reduced mortality or improved functional recovery after TBI (even in pediatric TBI). Current findings support that hypothermia should be initiated as soon as possible, for at least 48 h duration, and that outcome is worse when barbiturates are part of ICU management. Currently, available cooling techniques, including prehospital cooling protocols, expand and improve clinical management of therapeutic hypothermia. SUMMARY: Taking into consideration all results from clinical hypothermia TBI studies discussion has to be focused around the possibility that a better outcome could be achieved if protocols for therapeutic hypothermia are reviewed. It is possible that the negative effects of the cooling and the rewarming procedure currently overshadow the neuroprotective effects.
Cathy S De Deyne
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Current opinion in anaesthesiology     Volume:  23     ISSN:  1473-6500     ISO Abbreviation:  Curr Opin Anaesthesiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8813436     Medline TA:  Curr Opin Anaesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-62     Citation Subset:  IM    
Department of Anesthesiology and Critical Care Medicine, Ziekenhuis Oost-Limburg, Genk, Belgium Faculty of Medicine, University Hasselt, Hasselt, Belgium.
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MeSH Terms
Abdominal Injuries / complications*,  physiopathology,  therapy*
Compartment Syndromes / etiology*,  physiopathology,  surgery,  therapy*
Intensive Care
Intraoperative Care
Wounds and Injuries / complications*,  physiopathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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