| Therapeutic hypothermia for brain injury after cardiac arrest. | |
| | |
MedLine Citation:
|
PMID: 16969739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Morbidity and mortality in patients successfully resuscitated from cardiac arrest primarily depends on neurological outcome. Clinical trials of therapies directed toward reducing the extent of neuronal damage by means of pharmacological agents have been disappointing. To date, the only clinically effective tool for amelioration of brain damage by ischemia and reperfusion is mild to moderate induced hypothermia. The pathophysiology of global hypoxic-ischemic brain injury, the mechanisms by which hypothermia confers neuroprotection, and the encouraging beneficial effects of mild to moderate hypothermia in experimental studies and clinical trials are discussed. |
| | |
Authors:
|
Fred Rincon; Stephan A Mayer |
Related Documents
:
|
1421609 - Cardiac pathology following resuscitative circulatory support. direct mechanical ventri... 3399429 - Heart-rate spectral analysis: a noninvasive probe of cardiovascular regulation in criti... 18467889 - Thrombolysis and other drugs during cardiopulmonary resuscitation. 2919909 - Penetrating wounds to the heart: a wartime experience. 9161909 - Current concepts in cardiopulmonary resuscitation. 8752819 - Myocardial dysfunction after resuscitation from cardiac arrest: an example of global my... 697429 - Surgical correction of congenital heart disease in the adult: experience with 139 patie... 7833189 - Pericardial effusion after cardiac surgery: incidence, site, size, and haemodynamic con... 16969859 - Pathogenesis of cardiac conduction disorders in children genetic and histopathologic as... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Seminars in neurology Volume: 26 ISSN: 0271-8235 ISO Abbreviation: Semin Neurol Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-09-13 Completed Date: 2006-11-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8111343 Medline TA: Semin Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 387-95 Citation Subset: IM |
Affiliation:
|
Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology, Columbia University, New York, New York, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain
/
blood supply,
metabolism,
physiopathology* Brain Infarction / physiopathology, prevention & control, therapy* Cerebrovascular Circulation / physiology Heart Arrest / complications* Humans Hypothermia, Induced / adverse effects, standards, trends* Hypoxia-Ischemia, Brain / etiology, prevention & control, therapy* Reperfusion Injury / physiopathology, prevention & control, therapy Treatment Outcome Ventricular Fibrillation / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prehospital interventions to improve neurological outcome following cardiac arrest.
Next Document: Postresuscitative intensive care: neuroprotective strategies after cardiac arrest.