| Therapeutic hypothermia after cardiac arrest and myocardial infarction. | |
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MedLine Citation:
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PMID: 19137812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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About 17 million people worldwide die from cardiovascular diseases each year. Impaired neurologic function after sudden cardiac arrest is a major cause of death in these patients. Up to now, no specific post-arrest therapy was available to improve outcome. Recently, two randomized clinical trials of mild therapeutic hypothermia after successful resuscitation from cardiac arrest showed improvement of neurological outcome and reduced mortality. A broad implementation of this new therapy could save thousands of lives worldwide, as only 6 patients have to be treated to get one additional patient with favourable neurological recovery. At present, myocardial reperfusion by thrombolytic therapy or primary PCI as early as possible is the most effective therapy in patients with acute myocardial infarction. Mild therapeutic hypothermia might be a promising new therapy to prevent reperfusion injury after myocardial infarction, but its use in daily clinical routine cannot be recommended with the available evidence. |
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Authors:
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Michael Holzer; Wilhelm Behringer |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical anaesthesiology Volume: 22 ISSN: 1521-6896 ISO Abbreviation: Best Pract Res Clin Anaesthesiol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-13 Completed Date: 2009-02-23 Revised Date: 2011-04-28 |
Medline Journal Info:
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Nlm Unique ID: 101121446 Medline TA: Best Pract Res Clin Anaesthesiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 711-28 Citation Subset: IM |
Affiliation:
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Universitätsklinik für Notfallmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20/6D, 1090 Wien, Austria. michael.holzer@meduniwien.ac.at |
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| MeSH Terms | |
Descriptor/Qualifier:
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Heart Arrest
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complications* Humans Hypothermia, Induced / methods* Myocardial Infarction / complications* Nervous System Diseases / etiology, physiopathology, prevention & control* Randomized Controlled Trials as Topic Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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