| Therapeutic granulocyte transfusions for documented infections. A controlled trial in ninety-five infectious granulocytopenic episodes. | |
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MedLine Citation:
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PMID: 6751183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with granulocytopenia (granulocyte count less than 0.5 x 10(9)/L) and a documented infection were randomized to receive or not to receive daily granulocyte transfusions in addition to antimicrobial therapy. Thirty-four of 47 control patients responded to therapy compared to 30 of 48 transfused patients (type 2 error, pneumonia, or a soft tissue infection, respective response rates for the control and transfused patients were 11 of 11 and 11 of 16 (Yates' corrected chi-squared test, p = 0.12). Response rates for patients with gram-negative septicemia were lower but were influenced by recovery of bone marrow function. Eleven of 12 control patients and seven of seven transfused patients with recovery of marrow function survived the gram-negative septicemia. In contrast, 12 of 24 control patients and 12 of 25 transfused patients survived gram-negative septicemia and persistent granulocytopenia (type 2 error p = 0.13). Two thirds of all fatal infections were associated with an underlying disease refractory to medical therapy. Therapeutic granulocyte transfusions had no substantial benefit over optimal antimicrobial therapy alone in managing infected patients with granulocytopenia. |
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Authors:
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D J Winston; W G Ho; R P Gale |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of internal medicine Volume: 97 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1982-12-03 Completed Date: 1982-12-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 509-15 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abscess
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therapy Adolescent Adult Aged Agranulocytosis / complications, therapy* Anti-Bacterial Agents / therapeutic use Bacterial Infections / complications, therapy* Blood Transfusion* Cellulitis / therapy Child Child, Preschool Clinical Trials as Topic Female Granulocytes / transplantation* Humans Leukemia / complications Male Middle Aged Neoplasms / complications Pneumonia / therapy Sepsis / therapy |
| Grant Support | |
ID/Acronym/Agency:
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CA-15688/CA/NCI NIH HHS; CA-23175/CA/NCI NIH HHS; HD-62971/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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