Document Detail


Therapeutic granulocyte transfusions for documented infections. A controlled trial in ninety-five infectious granulocytopenic episodes.
MedLine Citation:
PMID:  6751183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with granulocytopenia (granulocyte count less than 0.5 x 10(9)/L) and a documented infection were randomized to receive or not to receive daily granulocyte transfusions in addition to antimicrobial therapy. Thirty-four of 47 control patients responded to therapy compared to 30 of 48 transfused patients (type 2 error, pneumonia, or a soft tissue infection, respective response rates for the control and transfused patients were 11 of 11 and 11 of 16 (Yates' corrected chi-squared test, p = 0.12). Response rates for patients with gram-negative septicemia were lower but were influenced by recovery of bone marrow function. Eleven of 12 control patients and seven of seven transfused patients with recovery of marrow function survived the gram-negative septicemia. In contrast, 12 of 24 control patients and 12 of 25 transfused patients survived gram-negative septicemia and persistent granulocytopenia (type 2 error p = 0.13). Two thirds of all fatal infections were associated with an underlying disease refractory to medical therapy. Therapeutic granulocyte transfusions had no substantial benefit over optimal antimicrobial therapy alone in managing infected patients with granulocytopenia.
Authors:
D J Winston; W G Ho; R P Gale
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  97     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abscess / therapy
Adolescent
Adult
Aged
Agranulocytosis / complications,  therapy*
Anti-Bacterial Agents / therapeutic use
Bacterial Infections / complications,  therapy*
Blood Transfusion*
Cellulitis / therapy
Child
Child, Preschool
Clinical Trials as Topic
Female
Granulocytes / transplantation*
Humans
Leukemia / complications
Male
Middle Aged
Neoplasms / complications
Pneumonia / therapy
Sepsis / therapy
Grant Support
ID/Acronym/Agency:
CA-15688/CA/NCI NIH HHS; CA-23175/CA/NCI NIH HHS; HD-62971/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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