Document Detail

Therapeutic failure in familial type II hyperlipoproteinemia.
MedLine Citation:
PMID:  183084     Owner:  NLM     Status:  MEDLINE    
The extended use of diet and cholestyramine therapy in familial type II hyperlipoproteinemia was examined in patients who previously participated in a short-term, double-blind trial. A striking secondary failure in therapeutic response during 4 yr of use of this therapy was noted with plasma cholesterol rising an average of 15%. A 3 mo, out-patient, follow-up study designed to reinforce patient motivation and dietary and drug adherence resulted in a prompt but partial reversal of this therapeutic deterioration in 16 patients. Additional inpatient studies confirmed that patient noncompliance with the dietary regimen was the major factor responsible for the secondary failure. Cholestyramine together with a low cholesterol diet can be an effective agent in familial type II hyperlipoproteinemia, given a comprehensive program of out-patient follow-up with continued emphasis on dietary principles and drug adherence.
L A Witters; P N Herbert; R S Shulman; R M Krauss; R I Levy
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  25     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1017-26     Citation Subset:  IM    
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MeSH Terms
Cholesterol / blood
Cholestyramine Resin / therapeutic use*
Follow-Up Studies
Hyperlipidemias / diet therapy,  genetics*,  therapy*
Lipoproteins, LDL / blood
Middle Aged
Triglycerides / blood
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Triglycerides; 11041-12-6/Cholestyramine Resin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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