Document Detail

Therapeutic efficacy of lipoic acid in combination with dimercaptosuccinic acid against lead-induced renal tubular defects and on isolated brush-border enzyme activities.
MedLine Citation:
PMID:  15135082     Owner:  NLM     Status:  MEDLINE    
The combined therapeutic potentials of lipoic acid and dimercaptosuccinic acid were compared against their sole administrations in restoring the altered lead sensitive indices in urine and isolated renal brush-border preparations. Toxicity was induced in male albino rats (Wistar strain) by administering lead acetate (0.2%) in drinking water for 5 weeks, followed by therapy comprising lipoic acid (25 mg/kg body weight) and dimercaptosuccinic acid (20 mg/kg body weight) solely as well as combined during the 6th week. Changes in kidney weights encountered upon lead administration improved after therapy with lipoic acid and dimercaptosuccinic acid. Renal integrity was assessed by measuring the activities of alkaline phosphatase, acid phosphatase, lactate dehydrogenase, leucine aminopeptidase, N-acetyl-beta-D-glucosaminidase, gamma-glutamyl transferase and beta-glucuronidase in urine along with some urinary constituents (urea, uric acid, creatinine, protein and phosphorous). The effects of lead were also studied on isolated brush-border enzymes (alkaline phosphatase, acid phosphatase, gamma-glutamyl transferase and beta-glucuronidase) that showed a decline upon its administration. Increased activities of urinary enzymes were accompanied by increase in the urinary constituents. Increase in renal lead content was paralleled by a drastic fall in the renal delta-aminolevulinic acid dehydratase and a rise in urinary lead levels. Relative to the administration of lead, the combined therapy showed betterment on the renal integrity with respect to the functional parameters assessed, thereby indicating its efficacy over the monotherapies.
Thylambal Rajagopalan Sivaprasad; Saroja Palanichamy Malarkodi; Palaninathan Varalakshmi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  147     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  259-71     Citation Subset:  IM    
Department of Medical Biochemistry, Dr. A.L.M. PGIBMS, University of Madras, Taramani Campus, Chennai 600113, India.
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MeSH Terms
5-Aminolevulinate Synthetase / metabolism
Antioxidants / therapeutic use*
Biological Markers / urine
Body Weight / drug effects
Chelating Agents / therapeutic use*
Disease Models, Animal
Drug Therapy, Combination
Kidney Cortex / drug effects,  enzymology,  pathology
Kidney Diseases / chemically induced,  drug therapy*,  enzymology
Kidney Tubules / drug effects,  enzymology
Lead Poisoning / complications,  drug therapy*,  pathology,  urine
Microvilli / drug effects*,  enzymology
Organ Size / drug effects
Organometallic Compounds / toxicity,  urine
Rats, Wistar
Succimer / therapeutic use*
Thioctic Acid / therapeutic use*
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Chelating Agents; 0/Organometallic Compounds; 301-04-2/lead acetate; 304-55-2/Succimer; 62-46-4/Thioctic Acid; EC Synthetase

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