Document Detail


Therapeutic efficacy of leukocytapheresis for procoagulant microparticles during hemophagocytic syndrome.
MedLine Citation:
PMID:  19127090     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemophagocytic syndrome (HPS) presents with signs of persistent remittent fever, hepatosplenomegaly, pancytopenia, hepatic dysfunction, and disseminated intravascular coagulation because of hypercytokinemia caused by activated T lymphocytes and macrophages. In recent years leukocytapheresis using a leukocyte removal filter (known as lymphocytapheresis, LCAP) has been applied to the treatment of various autoimmune diseases. The removal of activated monocytes during LCAP treatment appears useful for hypercytokinemia. We experienced a 32-year-old Japanese man with HPS with elevated tissue factor-enriched monocyte-derived microparticles (MDMPs) and pro-inflammatory cytokines/chemokines. Improvements in the level of MDMPs and hypercytokinemia were observed after LCAP treatment. LCAP treatment performed for HPS can be considered a therapeutic strategy for patients with a risk of fetal hemorrhage.
Authors:
Tei Asai; Shosaku Nomura; Kazuyoshi Ishii; Kohichi Ichikawa; Nao Umei; Katsutoshi Matsunami; Yoshio Matsuo; Yasuhide Kitazawa
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-01-05
Journal Detail:
Title:  Pathophysiology of haemostasis and thrombosis     Volume:  36     ISSN:  1424-8840     ISO Abbreviation:  Pathophysiol. Haemost. Thromb.     Publication Date:  2008  
Date Detail:
Created Date:  2009-01-07     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142710     Medline TA:  Pathophysiol Haemost Thromb     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Department of Emergency and Critical Care Medicine, Kansai Medical University Hirakata Hospital, Hirakata, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation
Cell-Derived Microparticles / pathology*
Humans
Leukapheresis*
Lymphohistiocytosis, Hemophagocytic / therapy*
Male
Monocytes / pathology
Thromboplastin
Treatment Outcome
Chemical
Reg. No./Substance:
9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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