Document Detail


Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance.
MedLine Citation:
PMID:  20144932     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combination therapy with artemesinin or non-artemesinin-based antimalarials (ACTs or NACTs) are known to retard the development and progression of drug resistance in Plasmodium falciparum (P. falciparum). The optimal antimalarial combinations in Africa are yet unknown. We evaluate the therapeutic efficacy and effects on gametocyte carriage of Artemether-Lumefantrine (AL) and Amodiaquine-Sulfalene/Pyrimethamine (ASP) in children with P. falciparum malaria in an endemic area. One-hundred and thirty-nine children aged ≤ 10 years with uncomplicated P. falciparum malaria were enrolled. The primary end points were adequate clinical and parasitological response (ACPR), late parasitological failure(LPF), late clinical failure (LCF) and early treatment failure (ETF). Polymerase chain reaction (PCR)-corrected cure rates on days 14-42 and gametocyte carriage rates were determined. Fever clearance time was significantly shorter (P = 0.009) with ASP, but parasite clearance time was similar with both regimens. Day 28 cure rates were 91.4 and 89.9% (PCR-corrected) for AL and ASP respectively. Both regimens were well tolerated. Overall, gametocyte carriage before and following treatment were similar. Both combinations were found effective and comparable for treatment of acute, uncomplicated, P. falciparum malaria.
Authors:
Henrietta U Okafor; Elvis N Shu; Tagbo Oguonu
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-08
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  56     ISSN:  1465-3664     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  398-406     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, College of Medicine, University of Nigeria, Enugu, Nigeria. huche57@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Amodiaquine / therapeutic use
Antimalarials / therapeutic use*
Artemisinins / therapeutic use*
Child, Preschool
Chloroquine / administration & dosage
Drug Combinations
Drug Resistance
Drug Therapy, Combination
Ethanolamines / therapeutic use
Female
Fluorenes / therapeutic use
Follow-Up Studies
Gametogenesis / drug effects*
Humans
Infant
Malaria, Falciparum / drug therapy*,  parasitology
Male
Nigeria
Plasmodium falciparum / drug effects*,  genetics,  growth & development
Polymerase Chain Reaction
Pyrimethamine / therapeutic use
Sulfalene / therapeutic use
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Drug Combinations; 0/Ethanolamines; 0/Fluorenes; 0/artemether; 0/artemether-lumefantrine combination; 152-47-6/Sulfalene; 54-05-7/Chloroquine; 58-14-0/Pyrimethamine; 63968-64-9/artemisinine; 82186-77-4/lumefantrine; 86-42-0/Amodiaquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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