| Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance. | |
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MedLine Citation:
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PMID: 20144932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Combination therapy with artemesinin or non-artemesinin-based antimalarials (ACTs or NACTs) are known to retard the development and progression of drug resistance in Plasmodium falciparum (P. falciparum). The optimal antimalarial combinations in Africa are yet unknown. We evaluate the therapeutic efficacy and effects on gametocyte carriage of Artemether-Lumefantrine (AL) and Amodiaquine-Sulfalene/Pyrimethamine (ASP) in children with P. falciparum malaria in an endemic area. One-hundred and thirty-nine children aged ≤ 10 years with uncomplicated P. falciparum malaria were enrolled. The primary end points were adequate clinical and parasitological response (ACPR), late parasitological failure(LPF), late clinical failure (LCF) and early treatment failure (ETF). Polymerase chain reaction (PCR)-corrected cure rates on days 14-42 and gametocyte carriage rates were determined. Fever clearance time was significantly shorter (P = 0.009) with ASP, but parasite clearance time was similar with both regimens. Day 28 cure rates were 91.4 and 89.9% (PCR-corrected) for AL and ASP respectively. Both regimens were well tolerated. Overall, gametocyte carriage before and following treatment were similar. Both combinations were found effective and comparable for treatment of acute, uncomplicated, P. falciparum malaria. |
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Authors:
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Henrietta U Okafor; Elvis N Shu; Tagbo Oguonu |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-08 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 56 ISSN: 1465-3664 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 398-406 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, College of Medicine, University of Nigeria, Enugu, Nigeria. huche57@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amodiaquine
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therapeutic use Antimalarials / therapeutic use* Artemisinins / therapeutic use* Child, Preschool Chloroquine / administration & dosage Drug Combinations Drug Resistance Drug Therapy, Combination Ethanolamines / therapeutic use Female Fluorenes / therapeutic use Follow-Up Studies Gametogenesis / drug effects* Humans Infant Malaria, Falciparum / drug therapy*, parasitology Male Nigeria Plasmodium falciparum / drug effects*, genetics, growth & development Polymerase Chain Reaction Pyrimethamine / therapeutic use Sulfalene / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Artemisinins; 0/Drug Combinations; 0/Ethanolamines; 0/Fluorenes; 0/artemether; 0/artemether-lumefantrine combination; 152-47-6/Sulfalene; 54-05-7/Chloroquine; 58-14-0/Pyrimethamine; 63968-64-9/artemisinine; 82186-77-4/lumefantrine; 86-42-0/Amodiaquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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